This causes the statue to turn into a boss which you can kill for a Key Piece. Alternatively you can defeat Isaac while holding The Polaroid to progress to the Chest and fight ?.ĭefeating The Lamb or ? once will make it possible to blow up the angel statues that appear in angel rooms. Once The Negative / Polaroid are unlocked, you can defeat Satan while holding The Negative to progress to the Dark Room and fight The Lamb. Defeating It Lives will always spawn an entrance to both Sheol and Cathedral without needing to get a devil / angel deal. If you get a devil / angel deal from the Mom's Heart fight, you can go into the devil / angel room and progress to Sheol / Cathedral to fight Satan / Isaac.ĭefeating Mom's Heart 11 times will turn Mom's Heart into It Lives. I highly recommend all players use the External Item Descriptions mod so you don't have to manually look up the effect of every item you find.ĭefeat Satan 5 times to unlock The Negative and Isaac 5 times to unlock The Polaroid. Achievements can then be unlocked even with mods and the debug console enabled. Let me know if there's any other big progression milestones that I should include.ĭefeat Mom 1 time (without mods or the debug console enabled) to unlock the Womb floors and Mom's Heart. So I decided to make a quick(ish) guide, mostly for my future self tbh. I'm starting my 3rd save file and still can't remember how a lot of early progression milestones are unlocked, and it's super obtuse trying to find it on the wiki. SPOILER WARNING if you're a new player who cares about that kind of thing.
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